Endocrine Abstracts

Objective: The goal of this paper is to investigate the effectiveness of antithyroidiennes, associated or not, with the thyroid hormone.Material and methods: Patients and their clinical histories were examined when each ambulatory patient was personally visited, for one year, by the author. 156 cases were examined (16 males and 140 females). The diagnoses were based on anamnesis, clinical exploration, TSH + thyroid hormone and bioquim determinations and ...

Generation of hydrogen peroxide (H2O2) in thyroid cells is essential for the synthesis of thyroid hormone. H2O2 is produced by the Dual Oxidase 2 (DUOX2) at the apical membrane of the thyrocyte, where it is required by thyroperoxidase for the iodination of thyroglobulin. A dual oxidase maturation factor 2 (DUOXA2) was recently identified as an endoplasmic reticulum-resident protein required for expression of DUOX2 activity. DUOX2 and...

Introduction: Poor metabolic control in type 1 diabetes mellitus (T1DM) is associated with micro and macrovascular complications. The implementation of interstitial glucose monitoring systems has contributed to the improvement of glycemic control in recent years.Objectives: Our main objective was to analyze the results of implementing flash glucose monitoring (FGM) devices after 1 year, and see if it managed to improve glycemic control in our patients.</...

Introduction: POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome is a rare multisystemic disease. Diagnosis requires two major criteria and at least one minor criterion. Major criteria include polineuropathy and a monoclonal plasma proliferative disorder (almost always lambda). Minor criteria include osteosclerotic bone lesions, Castleman disease, organomegaly (including lymphadenopathy), oedema, pleural effusion or ascites, e...

Metabolic syndrome and insulin resistance persist 5 years after remission of Cushing’s syndrome (CS). Adiponectin and visfatin are two adipokines highly expressed in adipose tissue. Adiponectin is reduced in obesity and insulin-resistant states; visfatin has been shown in some studies to be reduced in obesity. The aim was to evaluate visfatin and adiponectin levels, body composition, insulin resistance and prevalence of metabolic syndrome in a cohort of women with long-te...

Introduction: Low testosterone serum levels are associated with increased mortality in non-diabetic males. However, knowledge about the association between male hypogonadism and mortality among type 2 diabetic (T2DM) men is limited due to short follow-up periods in the few existing studies.Objective: To assess the association between hypogonadism and mortality in diabetic men.Material and methods: 263 unselected men with T2DM (mean...

Introduction: Gestational diabetes mellitus (GDM) is the metabolic disorder most frequently associated with pregnancy, presenting important maternal and fetal implications. Strict glycemic control through lifestyle measures and/or pharmacotherapy is essential to achieve adequate obstetric-perinatal results. The objective of this study is to compare baseline characteristics and perinatal results in patients diagnosed with GDM after performing oral glucose tolerance test (OGTT) ...

Introduction: Hyperparathyroidism in pregnancy is rare and is associated with significant maternal and fetal morbidity and mortality. Recognition can be challenging due to the inability to differentiate hypercalcaemia symptoms from those of pregnancy, studies suggest that up to 80% of cases may be undiagnosed. We report three cases of hyperparathyroidism in pregnancy at Royal Derby Hospital, investigations (Table 1) and management in these patients are reviewed.<p class="a...

Background and aim: Patients with GH deficiency (GHD) have increased risk of cerebrovascular events. The aim of this study was to evaluate the rate and factors associated with the occurrence of stroke, a major cause of death and disability, in adults with GHD.Patients and methods: Data from 15,188 GHD patients treated with GH replacement therapy (GHRT) enrolled in KIMS were analyzed. Stroke incidence rates were compared to rates from the Oxford Vascular ...

Aim: Acromegaly is associated with higher mortality and morbidity, and achieving disease control can be challenging. The aim of this study was to assess the morbidity and mortality associated with active acromegaly compared to patients in whom disease control was achieved.Methods: Retrospective analysis of all patients treated with acromegaly at a university hospital between 1948 and 2014 was performed. Mortality rates and development of new cardiovascul...